The Synergy of Combined Use of DMSO and Bronsted Acid (Ionic Liquid) as a Catalyst Part I: Efficient Niementowski Synthesis of Modified Quinazolinones

نویسندگان

  • Muthu Kumaradoss Kathiravan
  • Rajeshwar Rajendra Jalnapurkar
  • Aparna Surendra Chothe
  • Trupti Sameer Chitre
  • Riyaj Shaukat Tamboli
  • Kumar V. Srinivasan
چکیده

A new rapid and versatile approach using Ionic Liquid/DMSO as a chemical reagent for the synthesis of fused heterocyclic compounds in a highly efficient way is described. This method offers the advantages of proceeding in neutral conditions, giving high to excellent isolated yields (83-92%) for Niementowski synthesis with easy workup procedure. The inherent Bronsted acidity of ionic liquid and high polarity of both IL and DMSO resulted in a significant enhancement in the reaction rate.

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تاریخ انتشار 2011